1. komponenta

Lecture type	Total
Lectures	30
Seminar	15

* Load is given in academic hour (1 academic hour = 45 minutes)

COURSE CONTENT:
Introduction: importance of heterocycles. Aromatic heterocycles: structural types; nomenclature, reactivity. Tautomerism of heteroaromatic compounds. Nonaromatic heterocycles: structural types; nomenclature, reactivity. Anomeric effect. Ring synthesis. Cyclization reactions. Cycloaddition reactions Six-membered ring compounds with one heteroatom. Pyridines. Quinolines and isoquinolines. Five-membered ring compounds with one heteroatom. Pyrroles. Furans. Thiophenes. Indoles and related compounds. Benzofurans. Six-membered ring compounds with two or more heteroatoms. Pyrimidines and purines. Diazines, triazines and tetrazines. Oxazines and thiazines. Five-membered ring compounds with two or more heteroatoms. Imidazoles. Pyrazoles, triazoles and tetrazoles. Oxazoles and thiazoles and their benzo derivatives. Purines. Heterocycles in Biochemistry and Medicine.

LEARNING OUTCOMES:
- to be able to described structures of heterocyclic compounds and explain their physical and chemical properties;
- to compare the structure of heterocyclic compounds and their chemical reactivity;
- to implement fundamental knowledge of organic chemistry in planning of synthesis of heterocycles;
- to explain main reaction mechanisms in synthesis of compounds;
- to have a working knowledge of a set of modern synthetic methods related to the total synthesis of bioactive heterocyclic compounds;
- to present adequate skills in technical writing and oral presentations.

1. OBVEZNA LITERATURA:
   Julio Alvarez Builla, Juan Jose Vaquero, Jose Barluenga Editors(s): Modern Heterocyclic Chemistry, Wiley VCH Verlag GmbH Co. KGaA, 2011.
   J. A. Joule, K. Mills, Heterocyclic Chemistry, 5. izdanje, Blackwell Science, 2010.
   T.L. Gilchrist, Heterocyclic Chemistry, 3rd edition, Longmann, 1997.
2. DOPUNSKA LITERATURA:
   revijalni članci i znanstvene monografije

Izborni predmeti izvan odabranih grana - Regular study - Analytical and inorganic chemistry
Izborni predmeti organska kemija - Regular study - Analytical and organic chemistry
Izborni predmeti izvan odabranih grana - Regular study - Analytical and physical chemistry
Izborni predmeti izvan odabranih grana - Regular study - Analytical chemistry and biochemistry
Izborni predmeti organska kemija - Regular study - Biochemistry and organic chemistry
Izborni predmeti izvan odabranih grana - Regular study - Biochemistry and physical chemistry
Izborni predmeti organska kemija - Regular study - Inorganic and organic chemistry
Izborni predmeti izvan odabranih grana - Regular study - Inorganic and physical chemistry
Izborni predmeti izvan odabranih grana - Regular study - Inorganic chemistry and biochemistry
Izborni predmeti organska kemija - Regular study - Physical and organic chemistry

Izborni predmeti izvan odabranih grana - Regular study - Analytical and inorganic chemistry
Izborni predmeti organska kemija - Regular study - Analytical and organic chemistry
Izborni predmeti izvan odabranih grana - Regular study - Analytical and physical chemistry
Izborni predmeti izvan odabranih grana - Regular study - Analytical chemistry and biochemistry
Izborni predmeti organska kemija - Regular study - Biochemistry and organic chemistry
Izborni predmeti izvan odabranih grana - Regular study - Biochemistry and physical chemistry
Izborni predmeti organska kemija - Regular study - Inorganic and organic chemistry
Izborni predmeti izvan odabranih grana - Regular study - Inorganic and physical chemistry
Izborni predmeti izvan odabranih grana - Regular study - Inorganic chemistry and biochemistry
Izborni predmeti organska kemija - Regular study - Physical and organic chemistry