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Multidimensional NMR spectroscopy

Code: 44006
ECTS: 5.0
Lecturers in charge: prof. dr. sc. Predrag Novak - Lectures
Lecturers: Katarina Pičuljan - Seminar
Take exam: Studomat
Load:

1. komponenta

Lecture typeTotal
Lectures 30
Seminar 15
* Load is given in academic hour (1 academic hour = 45 minutes)
Description:
Basic principles of nuclear magnetic resonance. Nuclear spin and resonance. Pulse NMR. Time and frequency domain. The vector model. NMR Spectrometer. Spin interactions. Coherence. Polarisation transfer. The role of pulsed filed gradients. Double resonance and multi-pulse one-dimensional NMR techniques. Correlation techniques. Direct and indirect two-dimensional techniques. Nuclear Overhauser Effect. Homonuclear two-dimensional sequences: COSY, DQCOSY, NOESY, trNOESY, ROESY, TOCSY. Heteronuclear two-dimensional sequences: HETCOR, HMQC, HSQC, HMBC, HSQC-TOCSY. Solid state NMR. The application of multi-dimensional techniques for determination of 2D structure of organic and biomolecules. NMR in conformational analysis. The application of NMR techniques such as diffusion NMR spectroscopy, saturation transfer difference and SAR by NMR to study molecular interactions.
COURSE CONTENT:
Basic principles of nuclear magnetic resonance. Nuclear spin and resonance. Pulse NMR. Time and frequency domain. The vector model. Spin interactions. Coherence. Polarisation transfer. The role of pulsed filed gradients. Correlation techniques. Direct and indirect two-dimensional techniques. Homonuclear two-dimensional sequences: COSY, DQCOSY, NOESY, trNOESY, ROESY, TOCSY. Heteronuclear two-dimensional sequences: HETCOR, HMQC, HSQC, HMBC, HSQC-TOCSY. The application of multi-dimensional techniques for determination of 2D structure of organic and biomolecules. NMR in conformational analysis. The application of NMR techniques such as diffusion NMR spectroscopy, saturation transfer difference and SAR by NMR to study molecular interactions including macromolecules; proteins and nucleic acids
Literature:
  1. D. W. Claridge, High Resolution NMR Techniques in Organic Chemistry, Elsevier, Amsterdam, 2009.
  2. P. Novak i T. Jednačak, Strukturna analiza spojeva spektroskopskim metodama, TIVA Tiskara, Varaždin, 2013.
  3. H. Friebolin, Basic One- and Two-Dimensional NMR Spectroscopy, VCH, Weinheim, 2005.
  4. J. Keeler, Understanding NMR Spectroscopy, Wiley, Chichester, 2010.
  5. W.R. Croasmun, R.M.K. Carlson, Two-dimensional NMR spectroscopy- Application for chemists and biochemists, VCH, Cambridge, 1994.
  6. Solid state NMR spectroscopy Principles and Applications, ed. M.J. Duer, Wiley, 2007.
  7. S. Berger i S. Braun, 200 and More NMR Experiments, Wiley-VCH, Weinheim, 2004.
    scientific papers
1. semester
Izborni predmet analitička kemija - Mandatory smjer - Analytical and inorganic chemistry
Izborni predmet analitička kemija - Mandatory smjer - Analytical and organic chemistry
Izborni predmet analitička kemija - Mandatory smjer - Analytical and physical chemistry
Izborni predmet analitička kemija - Mandatory smjer - Analytical chemistry and biochemistry
Izborni predmeti izvan odabranih grana - Mandatory smjer - Biochemistry and organic chemistry
Izborni predmeti izvan odabranih grana - Mandatory smjer - Biochemistry and physical chemistry
Izborni predmeti izvan odabranih grana - Mandatory smjer - Inorganic and organic chemistry
Izborni predmeti izvan odabranih grana - Mandatory smjer - Inorganic and physical chemistry
Izborni predmeti izvan odabranih grana - Mandatory smjer - Inorganic chemistry and biochemistry
Izborni predmeti izvan odabranih grana - Mandatory smjer - Physical and organic chemistry

3. semester
Izborni predmet analitička kemija - Mandatory smjer - Analytical and inorganic chemistry
Izborni predmet analitička kemija - Mandatory smjer - Analytical and organic chemistry
Izborni predmet analitička kemija - Mandatory smjer - Analytical and physical chemistry
Izborni predmet analitička kemija - Mandatory smjer - Analytical chemistry and biochemistry
Izborni predmeti izvan odabranih grana - Mandatory smjer - Biochemistry and organic chemistry
Izborni predmeti izvan odabranih grana - Mandatory smjer - Biochemistry and physical chemistry
Izborni predmeti izvan odabranih grana - Mandatory smjer - Inorganic and organic chemistry
Izborni predmeti izvan odabranih grana - Mandatory smjer - Inorganic and physical chemistry
Izborni predmeti izvan odabranih grana - Mandatory smjer - Inorganic chemistry and biochemistry
Izborni predmeti izvan odabranih grana - Mandatory smjer - Physical and organic chemistry
Consultations schedule: