1. komponenta

Lecture type	Total
Lectures	15
Practicum	30

* Load is given in academic hour (1 academic hour = 45 minutes)

COURSE CONTENT
Integration of the latest knowledge about the human genome based on DNA sequence analysis.

LECTURES:
1. Introductory lecture, familiarization with the content and objectives of the course
2. Organization of the human genome, autosomal and sex chromosomes, structure of coding and non-coding regions
3. What makes us human? Evolution of gene structure. Comparison of human genome and great apes' genomes.
4. Linkage disequilibrium, explanation of the term, basic mathematical calculation, visualisation
5. and 6. Effects of evolutionary forces on the human genome. Selection and genetic drift, examples of the most famous adaptations.
7., 8. 9. Out of Africa - migration of modern humans, data based on mtDNA, Y chromosome and whole genome sequencing
10. Monogenetic traits, inheritance and mapping methods (linkage and exome sequencing)
11. Complex traits, inheritance and detection methods (association studies)
12. and 13. Human genome in personalized medicine- ADME genes, somatic mutations, examples from medical practice
14. Human genome in forensics, description of loci and detection methods
15. Neanderthal DNA. Comparison of Neanderthal DNA with modern human DNA, analysis of differences and similarities

1. Human Molecular Genetics, T. Strachan and A. Read, Garland Science 2010
2. Human Evolutionary Genetics: Origin, People and Diseases, M. Jobling, M. Hurles, T. Kivisild and C. Tyler-Smith, Garland publishing, 2013
3. The Human Genom, J.E. Richards, R. Scott Hawely, Elsevier Inc. 2011

Izborni predmeti - Biologija čovjeka - Regular study - Molecular Biology