1. komponenta

Lecture type	Total
Lectures	30
Seminar	30

* Load is given in academic hour (1 academic hour = 45 minutes)

LEARNING OUTCOMES:
Students will be able to

1. To explain the main steps in the process of carcinogenesis
2. To explain the importance of oncogenes, tumor suppressor genes and environmental factors in the development and progression of tumors
3. Point to the main factors which influence metastatic spread of cancer cells to diferent target tissue
4 To explain the mechamisms of immune recognition and immune control of cancer growth and progression
5 To apply about a new possibilities in early detection, diagnosing, therapy and prevetion of various tissue-specific cancer
6. To evaluate the basic principles of immunotherapy of tumors

COURSE CONTENT:
1. Tumor definition-malignant tumor-benign tumor-sporadic tumor-inherited (familiar) tumor
2. A process of carcinogenesis
3. Oncogenic viruses and viral carcinogenesis
4 Oncogenes and tumor suppressor genes in tumor formation
5. Epidemiology of cancer and environmental factors in tumorigenesis
6. Genetic and epigenetic factors
7. Genetic, metabolic and immunological barriers in tumor progression
8. Cell-cycle regulation and apopptosis,Telomeres and telomerase activity
9. Neoangiogenesis, the growth and progression of tumors
10. Metastasis of tumor-metastatic cascade, Interactions of invasive tumors with the immune system
11. Burnet theory of immune surveillance and tumor incidence
12. Principles of immunotherapy-tumor biotherapy
13. Tumor classification and principles of clinical research
14. Modern methods of treatment of malignant tumors

SEMINARS:
Part of teaching-related seminars based on broad awareness of educational content, discussion of topics, clarifying and linking of data items, the recommendation of route of administration and reaching conclusions. The seminars were based on the following:
topics:
New approaches in the treatment of cancer
Chronic inflammation and cancer development
Genetic instability and cancer
Basic signaling pathways and cancer
telomeric length, telomeric proteins and genomic instability in carcinogenesis
DNA repair and survival of tumor cells
Tumor stem cells
UV radiation, inflammation and oxidative stress
Hormones and tumor
Natural carcinogens in food
Flavonoids and their anti-tumor effect
Oncolytic viruses and tumors
Epigenetic changes and tumor

1. Boranić M. i sur. Karcinogeneza suvremena gledišta o podrijetlu malignih tumora. Medicinska naklada, Zagreb, 2000.
   
   Steven T. Rosen MD. The biology of sceletal metastasis, 2004, Culwer Academic Press Eds. Keller ET. And Chung WK.
2. Knowles M, Selby P. Introduction to the cellular and molecular biology of cancer, Oxford Univ Press, Oxford, 2010
3. Marko Turić, Krsto Kolarić , Damir Eljuga, Klinička onkokologija, Nakladni zavod Globus, 1996

Izborni predmeti - Regular study - Molecular Biology
Izborni predmeti - Regular module - Physiology and Immunobiology