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Bioenergetics

Code: 152828
ECTS: 8.0
Lecturers in charge: izv. prof. dr. sc. Branimir Bertoša - Lectures
Take exam: Studomat
Load:

1. komponenta

Lecture typeTotal
Lectures 15
Seminar 5
* Load is given in academic hour (1 academic hour = 45 minutes)
Description:
Introduction: thermodynamics in biochemistry. Molecular interpretation of thermodynamical principles. Thermodynamical properties of macromolecular solutions. Thermodynamics of equilibrium and nonequilibrium states. Reversible and irreversible processes. Mechanisms of endergonic processes in biological and biochemical systems. Metastability, chemical potential of functional groups in biochemical systems. Enzymatic complexes. Energetic potential in living cells. Thermodynamics of membrane transport. Stabilisation of protein structure. Stabilisation forces and interactions in process of protein folding. Structural and functional domains. Uncovalent interactions: strength, energy and distance dependence. Models for studding uncovalent interactions in biochemical systems, importance of solvation. Dynamics of proteins structure. Protein-ligand interactions and their thermodynamical properties. Analysis of experimental data. Equilibrium processes, equilibrium constants - measurements and interpretation. Energetics of enzyme catalysis, transition state theory, energy of activation. Influence of steric factors on enzyme catalysis. Conformational changes: molecular mechanisms, cooperativity, allosteric effects. Mechanisms of cooperativity. Negative cooperativity. Physiological importance of cooperativity. Examples.
description of instruction methods Lectures, seminars, consultations.
Literature:
  1. OBVEZNA LITERATURA:
    D. A. Harris: Bioenergetics at a Glance, Blackwell Scienece, Oxford 2005.
    K.E. van Holde, W.C. Johnson, P.S. Ho: "Principles of Phsical Biochemistry", Pretince Hall, Upper Saddle River, USA, 1998.
    Miller: "Essentials of chemical biology", J. Wiely, Chichester, 2008.
    G.U. Nienhaus: "Protein-Ligand Interactions - Methods and Application", Human Press Inc., Totowa, New Jeresy, 2005.
    R.M.J. Cotterill: "BIOPHYSICS (An Introduction)", J. Wiely, West Sussex, 2006.
    M. Flögel: Scripta biochemica: Bioenergetika, Enzimska kataliza, FBF, Zagreb 1993-1996.
    T. A. Waigh: "Applied Biophysics- A Molecular Approach for Physical Scientists", J. Wiely, West Sussex, 2007.
  2. DOPUNSKA LITERATURA:
    revijalni članci i znanstvene monografije
1. semester
Izborni kolegiji za smjer analitička kemija - Mandatory smjer - Analytical chemistry
Temeljni kolegiji iz biokemije - Mandatory smjer - Biochemistry
Izborni kolegiji za smjer anorganska i strukturna kemija - Mandatory smjer - Inorganic and structural chemistry
Izborni kolegiji za smjer organska kemija - Mandatory smjer - Organic chemistry
Izborni kolegiji za smjer fizikalna kemija - Mandatory smjer - Physical chemistry

3. semester
Izborni predmeti doktorski studij kemije - Mandatory smjer - Analytical chemistry
Izborni predmeti doktorski studij kemije - Mandatory smjer - Biochemistry
Izborni predmeti doktorski studij kemije - Mandatory smjer - Inorganic and structural chemistry
Izborni predmeti doktorski studij kemije - Mandatory smjer - Organic chemistry
Izborni predmeti doktorski studij kemije - Mandatory smjer - Physical chemistry
Consultations schedule: