Repository

Repository is empty

Poll

No polls currently selected on this page!

Biochemistry and Pathobiochemistry of Lipids and Lipoproteins

Code: 152836
ECTS: 5.0
Lecturers in charge: prof. dr. sc. Sasa Frank - Lectures
Take exam: Studomat
Load:

1. komponenta

Lecture typeTotal
Lectures 10
Seminar 5
* Load is given in academic hour (1 academic hour = 45 minutes)
Description:
1. Biochemical and biophysical characteristics of lipid molecules: triglycerides, fatty acids, cholesterol, cholesterol ester, phospholipids
2. Lipoproteins: composition, classification, biochemical/biophysical properties
3. Biogenesis and metabolism of triglyceride rich lipoproteins:Chilomikrons, VLDL,; the role of lipoprotein lipase (LPL), LPL-knock out mice-a model for human LPL-deficiency; why LPL-deficiency is lethal in mice but not in humans? How experimental gene therapy using recombinant LPL-adenovirus facilitates survival of LPL-deficient mice?
4. Biogenesis and metabolism of low density lipoprotein: Generation of LDL, LDL receptor, molecular mechanisms of regulation of LDL receptor synthesis; LDL-receptor deficiency in humans, mutations in LDL receptor and in PCSK9; drugs and approaches used for treatment of hypercholesterolemia: statins, LDL apheresis, gene therapy; new drugs in clinical trials: limitapide and mipomersen
5. HDL-its role in reverse cholesterol transport (RCT): the role of ABCA1 and ABCG1 in the first step of RCT; the role of SR-BI, LCAT and CETP in HDL maturation; the role of hepatic SR-BI for delivery of HDL associated cholesterol ester into liver
6. Pathogenesis of atherosclerosis-the role of LDL, HDL and macrophages; application of synthetic HDL (reconstituted HDL), apoAI mimetics and mutant apoAI in the treatment of atherosclerosis; experimental atherosclerosis
7. Endothelial lipase-modulator of abundance, structure and function of HDL
description of instruction methods Lectures, seminars, problem based learning,
description of course/module requirements
Literature:
  1. OBVEZNA LITERATURA:
    Lipoproteins: role in health and diseases (on-line free access book), Edited by S. Frank and G. Kostner
    http://www.intechopen.com/books/lipoproteins-role-in-health-and-diseases
    E.M. de Goma and D.J. Rader. Novel HDL-directed pharmacotherapeutic strategies. Nat.Rev.Cardiol. 2011; 2:1-12.
    P. Libby. Inflammation in Atherosclerosis. Arterioscler.Thromb.Vasc.Biol. 2012;32:2045-2051.
    J.F. Oram and J.W. Heinecke. ATP-Binding Cassette Transporter A1: A Cell Cholesterol Exporter That Protects Against cardiovascular Disease. Physiol.Rev. 2005; 85: 1343-1372.
    A.J. Luis. Atherosclerosis. Nature 2000; 407: 233-241.
    J.L. Goldstein and M.S. Brown. The LDL Receptor. Arterioscler.Thromb.Vasc.Biol. 2009; 29:431-438.
  2. DOPUNSKA LITERATURA:
    revijalni članci i znanstvene monografije
1. semester
Izborni kolegiji za smjer analitička kemija - Mandatory smjer - Analytical chemistry
Izborni kolegiji za smjer biokemija - Mandatory smjer - Biochemistry
Izborni kolegiji za smjer anorganska i strukturna kemija - Mandatory smjer - Inorganic and structural chemistry
Izborni kolegiji za smjer organska kemija - Mandatory smjer - Organic chemistry
Izborni kolegiji za smjer fizikalna kemija - Mandatory smjer - Physical chemistry

3. semester
Izborni predmeti doktorski studij kemije - Mandatory smjer - Analytical chemistry
Izborni predmeti doktorski studij kemije - Mandatory smjer - Biochemistry
Izborni predmeti doktorski studij kemije - Mandatory smjer - Inorganic and structural chemistry
Izborni predmeti doktorski studij kemije - Mandatory smjer - Organic chemistry
Izborni predmeti doktorski studij kemije - Mandatory smjer - Physical chemistry
Consultations schedule: