Department of...
 
Chemistry of...
 
Chemistry of Natural Organic Compounds
 
Code: 51069
ECTS: 4.0
Lecturers in charge: doc. dr. sc. Đani Škalamera - Lectures
Lecturers: Đani Škalamera - Exercises
Take exam: Studomat
Load:

1. komponenta

Lecture typeTotal
Lectures 30
Exercises 15
* Load is given in academic hour (1 academic hour = 45 minutes)
Description:
COURSE GOALS: Study of structures and biological activity of natural organic products and their synthesis and biosynthesis.

LEARNING OUTCOMES AT THE LEVEL OF THE PROGRAMME:
1. KNOWLEDGE AND UNDERSTANDING
1.2. demonstrate a thorough knowledge and understanding of the fundamental concepts in chemistry
1.4. demonstrate a thorough knowledge and understanding of the most important chemistry laws and theories
2. APPLYING KNOWLEDGE AND UNDERSTANDING
2.2. describe important aspects of chemical change
2.4. recognize and follow the logic of arguments, evaluate the adequacy of arguments and construct well supported arguments
3. MAKING JUDGMENTS
3.1. develop a critical scientific attitude towards research in general, and in particular by learning to critically evaluate arguments, assumptions, abstract concepts and data
4. COMMUNICATION SKILLS
4.1. clearly communicate effectively with pupils and colleague
4.4. use the written and oral English language communication skills that are essential for pursuing a career in physics, chemistry and education
5. LEARNING SKILLS
5.1. search for and use professional literature as well as any other sources of relevant information

LEARNING OUTCOMES SPECIFIC FOR THE COURSE:
1. to be able to described structures of natural organic products and explain their physical and chemical properties;
2. to compare the structure of natural organic products and their chemical reactivity;
3. to explain important biosynthetical processes of biologically active secondary metabolites;
4. to implement fundamental knowledge of organic chemistry in synthesis of natural organic products;
5. to explain main reaction mechanisms in synthesis and biosynthesis of organic compounds;
6. to develop adequate skills in technical writing and oral presentations.

COURSE DESCRIPTION:
Carbohydrates. Structural types, stereochemistry and nomenclature of monosaccharides. Sources and function. Chemistry of monosaccharides. Reactions of the hydroxyl group. Reactions at the anomeric centre. Glycosides. Formation and hydrolyses. Methods for determine the size of sugar rings. Oligosaccharides and polysaccharides. Determination of the structure and syntheses of polysaccharides. Structural characteristics and biological properties (glycogen, starch, cellulose, hitine). Nucleosides, nucleotides and polinucleotides: structure, reactivity and synthesis. Amino acids and proteins. Properties and stereochemistry of amino acids. Reactions of amino acids in vitro and in vivo. Syntheses of amino acids. Resolution of the amino acid racemates. Enantioselective syntheses of amino acids. Peptides and proteins. Syntheses of peptides and proteins. N-protecting groups. Activation and reaction: solid faze syntheses. Some linear and cyclic peptides and proteins. Terpenoids. General routes of biogenesis. Structure determination. Monoterpenoids. Sesquiterpenoids. Diterpenoids. Triterpenoids. Tetraterpenoids. Polyterpenoids. Steroids. Cholesterol. Bile acids. Sex hormones. Saponins. Vitamin D. Phytosterols. Stereochemistry, biogenesis, chemical syntheses and transformations. Phenolics. Structural types. Natural occurrence. Isolation and structure elucidation. Biogenesis via acetate pathway. Laboratory syntheses. Shikimic acid. Aromatic amino acids and phenylpropanoids. Biogenesis via shikimate pathway. Cinnamic acids, flavonoids and anthocyanidins. Alkaloids. Structural characteristics. Natural occurrence. Isolation and structure elucidation. Biosynthesis of alkaloids. Alkaloids derived from ornithine and lysine. Alkaloids derived from phenylalanine and tyrosine. Alkaloids derived from tryptophan. Synthesis of alkaloids.

REQUIREMENTS FOR STUDENTS:
Regular attendance of all course activities (lectures, seminars, partial tests).

GRADING AND ASSESSING THE WORK OF STUDENTS:
Written and oral exam. Credits can be obtained by taking partial tests.
Literature:
  1. J. Clayden, N. Greeves, S.Warren, P. Wothers, Organic Chemistry, 2. izdanje, Oxford University Press, 2012.
    P. M. Dewick, Medicinal Natural Products. A Biosynthetic Approach. 3. izdanje, Chichester, John Wiley & Sons, 2009.
  2. S. H. Pine: Organska kemija, Školska knjiga 1994.
    J. Mann, R.S. Davidson, J.B. Hobbs, D.V. Banthorpe, J.B. Harborne: Natural Products, Their Chemistry and Biological Significance, Longman, 1996.
7. semester
Izborni - kemija 3 - Mandatory studij - Physics and Chemistry Education

8. semester
Izborni - kemija 3 - Mandatory studij - Physics and Chemistry Education
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