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Structure, Function and Synthesis of Peptides/Proteins and their Conjugates

Code: 152820
ECTS: 5.0
Lecturers in charge: dr. sc. Ivanka Jerić - Lectures
Take exam: Studomat
Load:

1. komponenta

Lecture typeTotal
Lectures 15
* Load is given in academic hour (1 academic hour = 45 minutes)
Description:
Introduction
- peptides, proteins and their conjugates
- structure and role in biological processes
- model for the study of biological processes
Synthesis of peptides and proteins
- chemical vs enzymatic methods, chemo-enzymatic approach
- protecting groups, activation, deprotection, solution-phase vs solid-phase peptide synthesis
- modified peptides and peptidomimetics
Chemical methods for the synthesis of peptides and proteins
- stepwise synthesis
- fragment assembly
- directed assembly
- examples, advantages and disadvantages of certain methods
Glycoproteins, Lipoproteins, Phosphoproteins, Nucleopeptides
- structure and function
- synthetic methods
- application in research
Literature:
  1. OBVEZNA LITERATURA:
    F. Albericio, Developments in peptide and amide synthesis. Curr. Opin. Chem. Biol. 8 (2004) 211-221.
    L. P. Miranda i P. F. Alewood, Challenges for protein chemical synthesis in the 21st century: bridging genomics and proteomics. Biopolymers, 55 (2000) 217-226.
    G. Casi i D. Hilvert, Convergent protein synthesis. Curr. Opin. Struct. Biol. 13 (2003) 589-594.
    L. Liu, C. S. Benett i C.-H. Wong, Advances in glycoprotein synthesis. Chem. Commun. (2006) 21-33.
    D. Kadereit i H. Waldmann, Chemoenzymatic synthesis of lipidated peptides. Monatshefte für Chemie, 131 (2000) 571-584.
    J. S. McMurray, D. R. Coleman IV, W. Wang i M. L. Campbell, The synthesis of phosphopeptides. Biopolymers, 30 (2001) 3-31.
    S. Flohr, V. Lungmann i H. Waldmann, Chemoenzymatic synthesis of nucleopeptides. Chem. Eur. J. 5 (1999) 669-681.
  2. DOPUNSKA LITERATURA:
    revijalni članci i znanstvene monografije
1. semester
Izborni kolegiji za smjer analitička kemija - Mandatory smjer - Analytical chemistry
Izborni kolegiji za smjer biokemija - Mandatory smjer - Biochemistry
Izborni kolegiji za smjer anorganska i strukturna kemija - Mandatory smjer - Inorganic and structural chemistry
Izborni kolegiji za smjer organska kemija - Mandatory smjer - Organic chemistry
Izborni kolegiji za smjer fizikalna kemija - Mandatory smjer - Physical chemistry

3. semester
Izborni predmeti doktorski studij kemije - Mandatory smjer - Analytical chemistry
Izborni predmeti doktorski studij kemije - Mandatory smjer - Biochemistry
Izborni predmeti doktorski studij kemije - Mandatory smjer - Inorganic and structural chemistry
Izborni predmeti doktorski studij kemije - Mandatory smjer - Organic chemistry
Izborni predmeti doktorski studij kemije - Mandatory smjer - Physical chemistry
Consultations schedule: