Introduction
- peptides, proteins and their conjugates
- structure and role in biological processes
- model for the study of biological processes
Synthesis of peptides and proteins
- chemical vs enzymatic methods, chemo-enzymatic approach
- protecting groups, activation, deprotection, solution-phase vs solid-phase peptide synthesis
- modified peptides and peptidomimetics
Chemical methods for the synthesis of peptides and proteins
- stepwise synthesis
- fragment assembly
- directed assembly
- examples, advantages and disadvantages of certain methods
Glycoproteins, Lipoproteins, Phosphoproteins, Nucleopeptides
- structure and function
- synthetic methods
- application in research
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- OBVEZNA LITERATURA:
F. Albericio, Developments in peptide and amide synthesis. Curr. Opin. Chem. Biol. 8 (2004) 211-221.
L. P. Miranda i P. F. Alewood, Challenges for protein chemical synthesis in the 21st century: bridging genomics and proteomics. Biopolymers, 55 (2000) 217-226.
G. Casi i D. Hilvert, Convergent protein synthesis. Curr. Opin. Struct. Biol. 13 (2003) 589-594.
L. Liu, C. S. Benett i C.-H. Wong, Advances in glycoprotein synthesis. Chem. Commun. (2006) 21-33.
D. Kadereit i H. Waldmann, Chemoenzymatic synthesis of lipidated peptides. Monatshefte für Chemie, 131 (2000) 571-584.
J. S. McMurray, D. R. Coleman IV, W. Wang i M. L. Campbell, The synthesis of phosphopeptides. Biopolymers, 30 (2001) 3-31.
S. Flohr, V. Lungmann i H. Waldmann, Chemoenzymatic synthesis of nucleopeptides. Chem. Eur. J. 5 (1999) 669-681.
- DOPUNSKA LITERATURA:
revijalni članci i znanstvene monografije
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Pristupačnost
