1. komponenta

Lecture type	Total
Lectures	15
Seminar	15

The proposed subject has the task of introducing students to the basic mechanisms of autoimmunity with a special focus on autoimmune diseases and the differences between autoimmunity and autoimmune diseases that affect an increasing number of people worldwide.
Course content: Basics of immune reactions, tolerance, mechanisms of initiation of the autoimmune response process; the division of autoimmune diseases; the role of self-antigens and disorders of the immune system (immunodeficiency, hypersensitivity, autoimmunity); triggers of autoimmune reactions: viral infections, bacterial infections, drugs, molecular mimicry, hormones (stimulated and spontaneous onset of autoimmunity); structure, type and significance of autoantibodies; antigen-antibody complexes, T and B lymphocytes; gene factors such as genes for intracellular signalling and receptors (BANK1, BLK, PTPN2, PTPN22, TNFAIP3, TRAF1), genes for transcription factors (REL, STAT4, IRF5, NKX2-3), genes for cytokines and cytokine receptors, genes for membrane receptors and costimulatory molecules, genes for enzymes associated with autoimmune diseases (ARTS1, PADI4), autoantigens (INS, TSHR); genes of the HLA system; environmental factors influencing the development of autoimmune diseases and natural selection.

1. STANIČNA I MOLEKULARNA IMUNOLOGIJA, 8. izdanje., Abul K. Abbas , Andrew H. Lichtman, Shiv Pillai., Medicinska naklada, 2018.
2. IMUNOLOGIJA I IMUNOSNE BOLESTI PLUĆA., Dubravka Benčić, Drago Batinić, Branko Malenica i sur., Udžbenici Sveučilišta u Zagrebu,, 2010.
3. IMUNOLOGIJA, Igor Andreis, Medicinska naklada, 2010.

Izborni kolegiji - Regular - Physiology and Immunobiology