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Medical Genetics
Code: 60205
ECTS: 6.0
Lecturers in charge: izv. prof. dr. sc. Petra Korać - Lectures
Lecturers: Petra Korać - Seminar

Samira Smajlović - Practicum
Take exam: Studomat
English level:

0,0,0

The lecturer is not able to offer courses in English at this time.
Load:

1. komponenta

Lecture typeTotal
Lectures 30
Practicum 15
Seminar 15
* Load is given in academic hour (1 academic hour = 45 minutes)
Description:
LEARNING OUTCOMES:
1) Integrate knowledge from genetics, immunology, evolution and cell biology in order to explain mechanisms of disease development
2) Assess which methods are the most reliable for detection of certain aberrations based on the comparison of disease mechanism in different organs and systems
3) Discuss ethical issues in choosing samples and methods used in particular studies, in accordance with national and international laws and directives
4) Analyze differences between research and diagnostic procedures in biomedicine with the relation to specificity of both types of laboratories
5) Plan laboratory experiments in concordance with available type of samples and the most reliable methods

COURSE CONTENT:
Lectures:
1. Genetic inheritance, causes of mutations, types of mutations
2. Association of genetic aberrations and disease development
3. Genetics of reproductive and developmental processes
4. Genetic aberrations during development
5. Genetics of infectious diseases and its impact of host cells
6. Immunogenetics
7. Immunodeficiencies, transplantation
8. Autoimmune diseases and hypersensitivity reactions
9. Tumor pathobiology
10. Genetic basis of malignant diseases
11. Genetics of mental disorders
12. Types of samples in biomedicine
13. Types of studies in human genetics and biomarker evaluation
14. Development of new therapies
15. Biomedical ethics

Seminars:
1. Tumor markers
2. Clonality in hematological disorders
3. Prenatal diagnostics
4. Cell and tissue banks
5. Classification of malignant diseases

Practicals:
1. DNA isolation from archived tissue
2. Basic tissue staining and analysis of tumor tissue
3. Assessment of B cell clonality
4. Immunohistochemistry
5. Fluorescent in situ hybridization
Literature:
  1. Rasko I i Downes CS: Genes in Medicine, Chapman & Hall, 1995
  2. Strachan T i Read A: Human molecular genetics, Garland Science, 2011
3. semester
Izborni predmeti - Genetika - Mandatory studij - Molecular Biology
Consultations schedule: