|Public phone number:||+385 1 4606 132|
|Internal phone number:||6132|
|Department:||Division of Physical Chemistry|
Education at Department of Chemistry, Faculty of Science, University of Zagreb: Diploma thesis (Chemistry, 2001); Doctoral thesis (Chemistry, 2007).
Affiliation and current position: Associate Professor, Division of Physical Chemistry, Department of Chemistry, Faculty of Science, University of Zagreb (2015–).
Previous positions: Assistant Professor, Division of Physical Chemistry, Department of Chemistry, Faculty of Science, University of Zagreb (2012–2015). Research Associate (2009–2012), Senior Assistant (2007–2009), Assistant (2001–2007), Laboratory for Chemical and Biological Crystallography, Division of Physical Chemistry, "Ruđer Bošković" Institute, Zagreb, Croatia.
Visits to foreign research and education institutions: 2008–2009 Postdoctoral position, Department of Statistical and Biological Physics, "International School for Advanced Studies (SISSA)", Trieste, Italy.
Research interest: Investigation of biologically important molecules (systems) using computational methods (molecular mechanics, molecular dynamics, Monte Carlo conformational search, Random Acceleration Molecular Dynamics, 3D-QSAR). The selection of biological systems for research is based on biological relevance, access to experimental data and possibility of collaboration with experimentalists. Systems that are in the focus of present investigations: hydrolytic enzymes from GDSL family, purine nucleoside phosphorylase (PNP) from Escherichia coli, heterocyclic compounds with antitumor activity.
Scientific papers: co-author of 37 scientific papers, 32 of them are in journals indexed in Current Contents database. Average impact factor of scientific publications is 3.6. Number of citations is above 500.
Awards and recognitions and memberships: The Annual Award of "The Society of University Teachers, Scholars and Other Scientists – Zagreb" for young scientists and artists in 2008. EMBO fellowship for "EMBO Course on Biomolecular simulation", Institute Pasteur, Paris, France, 18. 07. – 25. 07. 2004.
Participation in research projects:
Principal investigator of research projects:
2021 – "Managanese metalosensors" funds provided by Croatian Science Foundation (cca 200 000 EUR).
2020 – European project "MARILIA" funds provided EU funds in the frame of Horizon2020 (total value of 2 000 000 EUR, funds for University of Zagreb cca 195 000 EUR).
2011 -2013 bilateral project with Germany "Biocatalysis of bacterial hydrolases of the GDSL–superfamily studied by a multidisciplinary approach"
2012 scientific project "Substrate promiscuity of bacterial SGNH hydrolases" funds provided by Croatian Academy of Science and Art.
Project collaborator of 11 reseasrch projects including the FP6 project "Reinforcement of the Centre for Computational Solutions in the Life Sciences" (2007-2010).
Note: this list of papers is located in an maintained by the Ruđer Bošković Institute which is in charge of the Croatian Scientific Bibliography Database (CROSBI). This link will take you to the appropriate CROSBI page of this person, containing a list of papers they have themselves entered in the database.
T. Dražić, S. Kopf, J. Corridan, M. M. Leuthold, B. Bertoša, C. D. Klein, Peptide-β-lactam Inhibitors of Dengue and West Nile Virus NS2B-NS3 Protease Display Two Distinct Binding Modes, J. Med. Chem. 63(1) (2020) 140-156.
M. Narczyk, B. Bertoša, L. Papa, V. Vuković, I. Leščić Ašler, B. Wielgus-Kutrowska, A. Bzowska, M. Luić, Z. Štefanić, Helicobacter pylori purine nucleoside phosphorylase shows new distribution patterns of open and closed active site conformations and unusual biochemical features, FEBS J., 285 (2018) 1305-1325.