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Biotransformation of Drugs and Xenobiotics

Code: 152835
ECTS: 5.0
Lecturers in charge: dr. sc. Ruža Frkanec - Lectures
Take exam: Studomat

1. komponenta

Lecture typeTotal
Lectures 15
* Load is given in academic hour (1 academic hour = 45 minutes)
Biotransformation of drugs and endogenous compounds catalyzed by specific enzymes. Oxidations and reductions (dehydrogenases, aminooxidases, xantin oxidases, cytochrome P-450). Hydrolysis (esterases, amidases, lipases, penicillinases). Acetylation and acylation (N-acetyltransferases, N-acyltransferases). Glucuronidation (UDP-glucuronyltransferases). Sulfoconjugation (sulfotransferases). Conjugation with glutathione (glutathiontransferases). Examples of biotransformation of drugs for each group of reactions. Structure-activity relationship. Genetic polymorphism. Inhibition and induction of enzymes involved in biotransformation of drugs. Mechanism of toxic metabolites formation.
    Goodman & Gilmans the pharmacological basis of therapeutics / editor-in-chief, Laurence L. Brunton; editors, Randa Hilal-Dandan, Bjoern C. Knollmann. 13th Edition, McGraw-Hill Medical, New York 2018.
    M. D. Coleman: Human Drug Metabolism An Introduction. Second Edition, Wiley and Blackwell,UK, 2010.
    D. Maysinger, T. Žanić-Grubišić: Kemijske osnove biotransformacije lijekova, Školska knjiga, Zagreb 1989.
    Slobodan Rendić, Marica Medić-Šarić, Metabolizam lijekova i odabranih ksenobitika, Medicinska naklada, Zagreb, 2013.
    A.Y.H. Lu: Individual Variability in Drug Therapy and Drug Safety, .Drug Metab. Dispos. 1998; 26: 1217-1222.
    M. Ingelman-Sundberg: Pharmacogenetics of cytochrome P450 and its applications in drug therapy: The past, present and future. Trends Pharmacol. Sci. 2004; 25 (4): 193-200.
    revijalni članci i znanstvene monografije
Consultations schedule: