Introduction to solid state chemistry of drug. Importance of crystal structures in the research, development, production and application of active substances. Crystal growth and crystallization processes, the shape and size of the particles. Polymorphic form, solvates and hydrates and amorphous state. Hydrogen bonds and other no covalent interactions. Use of none no covalent interaction in the creation of new materials to improve the properties. Methods for the analysis of solids. Physical and chemical transformations. Phase diagrams of multicomponents systems. Interactions in multiphase systems. Compatibility and incompatibility of substances in mixtures. Intellectual property in the field of chemistry and pharmacy, and related fields.
- OBVEZNA LITERAUTURA:
Stephen R. Byrn, Ralph R. Pfeiffer, and Joseph G. Stowell, Solid-State Chemistry of Drugs SSCI inc, West Lafayette 2001.
Harry G. Brittain (Ed.), Physical Characterization of Pharmaceutical Solids New York Marcel Dekker, Inc., 1995.
S. Myerson, D. A. Green and P. Meenan, Crystal Growth of Organic Materials, American Chemical Society, Washington 1995.
M. Dekker, Polymorphism in Pharmaceutical Solids, Dekker, Inc., New Yor 1999.
R. G. Desiraju The crystal as a Supramolecular Entity, Wiley, Chichester 1996.
J. Bernstein Polymorphism in Molecular Crystals, Oxford University Press 2002.
- DOPUNSKA LITERATURA:
revijalni članci i znanstvene monografije