COURSE CONTENT
1-2. Supramolecular synthons in crystal engineering 3. Targeted solid phases (coordination polymers and metal-organic frameworks, clathrates, inclusion compounds) 4-5. Methods of analysis (X-ray diffraction, thermal analysis, IR-spectroscopy, AFM, SEM, TEM, DLS) 6-8. Design strategies (molecular library, symmetry interactions, molecular panels, molecular tectons, nanocrystals) 9-10. Computational and preparative methods (solvent-free and solvent-based synthesis, sound and ultra-sound assisted reactions, liquid phase initiated phase transitions) 11-12. Applications (pharmaceutical co-crystals, electronic materials, targeting properties, stability control, gas storage, separations, peptide materials, optically active materials) 13. Crystal engineering on surfaces 14-15. Historical overview up to 2000. (Kitaigorodski, Schmidt, Etter, Desiraju, Zaworotko, Atwood, Gokel, Braga, Wuest, Aakeröy, Jones, McGillivray). Methodology: Subjects are presented in various ways (presentations, discussions, invited lectures, homeworks, student seminars). Course includes e-learning with interactive web-materials.
LEARNING OUTCOMES
LO_1 To list and to explain intermolecular interactions that are relevant for crystal engineering
LO_2 To list and to explain design strategies of crystal engineering
LO_3 To list and to describe the use of computational and preparative methods of crystal engineering
LO_4 To explain the term cocrystal and to describe their uses
LO_5 To propose the solution for specificaly defined (given or selected) crystal engineering problem
LO_6 To describe the strategy of crystal engineering on surfaces
LO_7 To analyze and to give a critical evaluation of a crystal engineering scientific paper
LO_8 To write a short essay on given crystal engineering subject and to use proper terminology
LO_9 To give a short oral lecture on given crystal engineering subject
LO_10 To give a short historical review (written or oral) of the development of crystal engineering (before 2005)
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Pristupačnost
