Department of...
 
Fundamentals in...
 
Fundamentals in Chemistry of Natural Organic...
 
Code: 73833
ECTS: 5.0
Lecturers in charge: doc. dr. sc. Đani Škalamera - Lectures
Lecturers: Đani Škalamera - Seminar
Take exam: Studomat
English level:

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The lecturer is not able to offer courses in English at this time.
Load:

1. komponenta

Lecture typeTotal
Lectures 30
Seminar 15
* Load is given in academic hour (1 academic hour = 45 minutes)
Description:
COURSE CONTENT:
1. Carbohydrates. Structural types, stereochemistry and nomenclature of monosaccharides. Sources and function. Chemistry of monosaccharides. Reactions of the hydroxyl group. Reactions at the anomeric centre. Glycosides. Formation and hydrolyses. Methods for determine the size of sugar rings. Oligosaccharides and polysaccharides. Determination of the structure and syntheses of polysaccharides. Structural characteristics and biological properties (glycogen, starch, cellulose, hitine).
2. Nucleosides, nucleotides and polinucleotides: structure, reactivity and synthesis.
3. Amino acids and proteins. Properties and stereochemistry of amino acids. Reactions of amino acids in vitro and in vivo. Syntheses of amino acids. Resolution of the amino acid racemates. Enantioselective syntheses of amino acids. Peptides and proteins. Syntheses of peptides and proteins. N-protecting groups. Activation and reaction: solid faze syntheses. Some linear and cyclic peptides and proteins.
4. Terpenoids. General routes of biogenesis. Structure determination. Monoterpenoids. Sesquiterpenoids. Diterpenoids. Triterpenoids. Tetraterpenoids. Polyterpenoids. Steroids. Cholesterol. Bile acids. Sex hormones. Saponins. Vitamin D. Phytosterols. Stereochemistry, biogenesis, chemical syntheses and transformations.
5. Phenolics. Structural types. Natural occurrence. Isolation and structure elucidation. Biogenesis via acetate pathway. Laboratory syntheses. Shikimic acid. Aromatic amino acids and phenylpropanoids. Biogenesis via shikimate pathway. Cinnamic acids, flavonoids and anthocyanidins.
6. Alkaloids. Structural characteristics. Natural occurrence. Isolation and structure elucidation. Biosynthesis of alkaloids. Alkaloids derived from ornithine and lysine. Alkaloids derived from phenylalanine and tyrosine. Alkaloids derived from tryptophan. Synthesis of alkaloids.

LEARNING OUTCOMES:
- to be able to described structures of natural organic products and explain their physical and chemical properties;
- to compare the structure of natural organic products and their chemical reactivity;
- to explain important biosynthetical processes of biologically active secondary metabolites;
- to implement fundamental knowledge of organic chemistry in synthesis of natural organic products;
- to explain main reaction mechanisms in synthesis and biosynthesis of organic compounds;
- to develop adequate skills in technical writing and oral presentations.
Literature:
  1. J. Clayden, N. Greeves, S.Warren, P. Wothers, Organic Chemistry, 2. izdanje, Oxford University Press, 2012.
    P. M. Dewick, Medicinal Natural Products. A Biosynthetic Approach. 3. izdanje, Chichester, John Wiley & Sons, 2009.
  2. S. H. Pine: Organska kemija, Školska knjiga 1994.
    J. Mann, R.S. Davidson, J.B. Hobbs, D.V. Banthorpe, J.B. Harborne: Natural Products, Their Chemistry and Biological Significance, Longman, 1996.
Prerequisit for:
Enrollment :
Passed : Organic Chemistry
4. semester
Izborni predmeti - Mandatory studij - Molecular Biology
Consultations schedule:
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