About employee

prof. dr. sc. Ines Primožič

Title: Full Professor

Location:
316
Public phone number:
+385 1 4606 408
Internal phone number:
6408

Teaching duties

university undergraduate

university graduate

university integrated undergraduate and graduate

university doctoral

Biography

 Education: PhD (Chemistry, Organic Chemistry, 2002); Master thesis (Chemistry, Organic Chemistry, 1998); Diploma thesis (Chemistry, Organic Chemistry, 1994) at the Faculty of Science, University of Zagreb.

Affiliation and current position: Division of Organic Chemistry, Department of Chemistry, Faculty of Science, University of Zagreb; Associate Professor (2012–).

Previous positions: Assistant Professor (2006-2012); Senior Assistant (2002-2006); Assistant (1995-2002), Division of Organic Chemistry, Department of Chemistry, Faculty of Science, University of Zagreb.

Teaching: Undergraduate studies (Organic Chemistry Laboratory 2, Introduction to Natural Products Chemistry), Graduate studies (Heterocyclic Chemistry, Natural Products Chemistry, Advanced Organic Chemistry Laboratory), Postgraduate Study (Stereoselective synthesis and catalysis in organic chemistry, Modern methods of heterocyclic synthesis).

Visits to foreign research and education institutions: Institut für Organische Chemie, Leopold-Franzens Universität Innsbruck, Innsbruck, Austria, postdoctoral scholarship Lise Meitner (Fonds zur Förderung der wissenschaftlichen Forschung, Austria) one year, March 2004. and postdoctoral scholarship Prof. Dr. Bernhard Kräutler, project "Chlorophyll Breakdown in Higher Plants – Chemical and Enzymatic Paths to Chlorophyll Catabolites", January-February 2004. Institute of Plant Sciences, University of Bern, Bern, Switzerland, Prof. Dr. Urs Feller, several short visits as guest-researcher during 2004.

Research interest:

Primary: Design and synthesis of heterocyclic compounds as potential bioactive compounds. Stereoselective organic syntheses. Resolution of racemic compounds by enzyme catalyzed reactions. Kinetics and molecular modelling studies of enzyme catalyzed reactions. Design and synthesis of oximes, potential antidotes for organophosphorus poisoning. Secondary: Syntheses of dissymmetric surfactants.

Scientific papers: Coauthor in 39 scientific papers indexed in Science Citation Index Expanded Index (SCI-EXP), two review articles and one conference note.

Awards, recognitions and memberships: Scholarship Lise Meitner, Fonds zur Förderung der wissenschaftlichen Forschung, Austria (2004). Assoc. Editor in the scientific journal Croatica Chemica Acta (http://hrcak.srce.hr/cca) (2010–). Collaborator in the project Education of Young Teachers in Natural Sciences (grant no. 6422021161/2002), OSI program 11661300 Faculty Development (2002–2003) by Institute Open Society – Croatia. Member of the Croatian Chemical Society and the Croatian Society of Biochemistry and Molecular Biology.

 

Croatian Scientific Bibliography CROSBI - Ines Primožič

List of select publications

Zandona, Antonio; Katalinić, Maja; Šinko, Goran; Radman Kastelic, Andreja; Primožič, Ines; Kovarik, Zrinka, Targeting Organophosphorus Compounds Poisoning by Novel quinuclidine-3 Oximes: Development of Butyrylcholinesterase-Based Bioscavengers Archives of toxicology (2020) doi:10.1007/s00204-020-02811-5

Radman Kastelic, Andreja; Odžak, Renata; Pezdirc, Iskra; Sović, Karlo; Hrenar, Tomica; Čipak Gašparović, Ana; Skočibušić, Mirjana; Primožič, Ines, New and potent quinuclidine based antimicrobial agents Molecules, 24 (2019), 14; 2675-2692 doi:10.3390/molecules24142675

Bazina, Linda; Maravić, Ana; Krce, Lucija; Soldo, Barbara; Odžak, Renata; Bučević Popović, Viljemka; Aviani, Ivica; Primožič, Ines; Šprung, Matilda, Discovery of novel quaternary ammonium compounds based on quinuclidine-3-ol as new potential antimicrobial candidates European journal of medicinal chemistry, 163 (2019), -; 626-635 doi:10.1016/j.ejmech.2018.12.023

Bosak, Anita; Ramić, Alma; Šmidlehner, Tamara; Hrenar, Tomica; Primožič, Ines; Kovarik, Zrinka, Design and evaluation of selective butyrylcholinesterase inhibitors based on Cinchona alkaloid scaffold // PLoS One, 1 (2018), 1; 1-18 doi:10.1371/journal.pone.0205193

Tomica Hrenar, Ines Primožič, Domagoj Fijan, Maja Majerić Elenkov, Conformational analysis of spiro-epoxides by principal component analysis of molecular dynamics trajectories Physical chemistry chemical physics 19 (2017) 31706-31713.

Maja Katalinić, Nikolina Maček Hrvat, Krešimir Baumann, Sara Morasi Piperčić, Sandro Makarić, Srđanka Tomić, Ozren Jović, Tomica Hrenar, Ante Miličević, Dubravko Jelić, Suzana Žunec, Ines Primožič,* Zrinka Kovarik,* A comprehensive evaluation of novel oximes in creation of butyrylcholinesterase-based nerve agent bioscavengers Toxicology and Applied Pharmacology. 310 (2016) 195-204.

Ana Mikleušević, Ines Primožič, Tomica Hrenar, Branka Salopek-Sondi, Lixia Tang, Maja Majerić Elenkov Azidolysis of epoxides catalysed by the halohydrin dehalogenase from Arthrobacter sp. AD2 and a mutant with enhanced enantioselectivity: an (S)-selective HHDH Tetrahedron: asymmetry. 27 (2016) 930-935.

List of select projects

  • Head of the project Breakdown of Chlorophyll: Biochemicial Properties of Red Chlorophyll Catabolite Reductase, Institut für Organische Chemie, Leopold-Franzens Universität Innsbruck, (Fonds zur Förderung der wissenschaftlichen Forschung, Austrija, Lise Meitner scholarship, M805-B11 2004).
  • Projects funded by the Croatian Ministry of Science, Education and Sports: Synthesis and biological activity of antidotes for organophosphorus compounds (project leader Z. Binenfeld, 1995-1996); Synthesis of saccharides and antidotes for organophosphorus compounds (S. Tomić-Pisarović, 1996-2001); Synthesis of polycyclic derivatives as potential inhibitors of TNF-α (with Pliva Croatia d.d., S. Tomić-Pisarović, 1999-2002); Enzymic transformation of saccharides and quinuclidines (S. Tomić-Pisarović, 2002-2006); Synthesis and enzymic transformation of biologically active compounds (S. Tomić-Pisarović, 2007-2013): synthesis of antidotes for organophosphorus poisoning, enzymatic transformations of chiral quinuclidinium compounds, inhibitors of butyrylcholinesterase.
  • Unity through Knowledge Fund - UKF: Biocatalytic application of halohydrin dehalogenases for production of chiral building blocks (Maja Majerić Elenkov, 2009-2011).
  • Challenging organic syntheses inspired by nature - from natural products chemistry to drug discovery, COST Action CM1407: 2015-2019
  • Multi-target paradigm for innovative ligand identification in the drug discovery process, COST Action CA15135: 2017-2021
  • HrZZ Croatian science foundation Metallosupramolecular architectures and inorganic-organic polyoxometalate based hybrides (V. Vrdoljak, 2017-2021)
  • HrZZ Croatian science foundation Activity and in silico guided design of bioactive small molecules (T. Hrenar, 2017-2021)