Biotransformation of drugs and endogenous compounds catalyzed by specific enzymes. Oxidations and reductions (dehydrogenases, aminooxidases, xantin oxidases, cytochrome P-450). Hydrolysis (esterases, amidases, lipases, penicillinases). Acetylation and acylation (N-acetyltransferases, N-acyltransferases). Glucuronidation (UDP-glucuronyltransferases). Sulfoconjugation (sulfotransferases). Conjugation with glutathione (glutathiontransferases). Examples of biotransformation of drugs for each group of reactions. Structure-activity relationship. Genetic polymorphism. Inhibition and induction of enzymes involved in biotransformation of drugs. Mechanism of toxic metabolites formation.
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- OBVEZNA LITERATURA:
Goodman & Gilmans the pharmacological basis of therapeutics / editor-in-chief, Laurence L. Brunton; editors, Randa Hilal-Dandan, Bjoern C. Knollmann. 13th Edition, McGraw-Hill Medical, New York 2018.
M. D. Coleman: Human Drug Metabolism An Introduction. Second Edition, Wiley and Blackwell,UK, 2010.
D. Maysinger, T. Žanić-Grubišić: Kemijske osnove biotransformacije lijekova, Školska knjiga, Zagreb 1989.
Slobodan Rendić, Marica Medić-Šarić, Metabolizam lijekova i odabranih ksenobitika, Medicinska naklada, Zagreb, 2013.
A.Y.H. Lu: Individual Variability in Drug Therapy and Drug Safety, .Drug Metab. Dispos. 1998; 26: 1217-1222.
M. Ingelman-Sundberg: Pharmacogenetics of cytochrome P450 and its applications in drug therapy: The past, present and future. Trends Pharmacol. Sci. 2004; 25 (4): 193-200.
- DOPUNSKA LITERATURA:
revijalni članci i znanstvene monografije
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