PRINCIPLES OF PHYSICAL-ORGANIC CHEMISTRY: Theoretical considerations, Isotope effects, Correlations of structure and reactivity, Solvent effects, Acids and bases, electrophiles and nucleophiles, Catalysis. SELECTED REACTION MECHANISMS: Substitution reactions at saturated carbon, Neighboring group participation, Elimination reactions, Polar addition reactions, Reactions of carbonyl group, Nucleophilic and electrophilic substitution at aromatic carbon, Pericyclic reactions.
EXPECTED COMPETENCES TO BE ACQUIRED:
Students will be able to
- explain the types and causes of isotope effects, and describe their usage in organic mechanisms analysis,
- explain the basic ideas behind the correlation between structure and reactivity,
- explain the solvent effects on organic reactions,
- deduce the relative stabilities of reactive intermediates and transition states,
- identify all most important types of organic reaction mechanisms,
- use tools of physical-organic chemistry to deduce details of organic reaction mechamisms.