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Regulation of Gene Expression, Post-translational Modifications and Protein Transport in the Cell

Code: 152827
ECTS: 5.0
Lecturers in charge: doc. dr. sc. Jasmina Rokov Plavec - Lectures
prof. dr. sc. Đurđica Ugarković - Lectures
prof. dr. sc. Slobodan Barbarić - Lectures
Take exam: Studomat

1. komponenta

Lecture typeTotal
Lectures 15
* Load is given in academic hour (1 academic hour = 45 minutes)
Control of gene expression: molecular mechanisms of transcriptional regulation in prokaryotes. Regulation of transcription - initiation in eukaryotes (cis-regulatory elements, general and specific transcription factors). Mechanisms of transcription factor activity regulation. Role of chromatin structure in transcription regulation (covalent modifications in histone tails and chromatin structure remodelling). Methods for analyzing protein-DNA and protein-protein interactions and chromatin structure analysis.
Post-transcriptional modification and processing of pre-mRNA (alternative splicing).
Transport of proteins through secretory pathways and into cell organelles. Co-translational translocation of secretory proteins across the ER membrane. Secretory pathway and vesicular transport. Signal sequences and molecular mechanisms of protein transport in mitochondria and nucleus.
Post-translational modifications of proteins. Protein folding, glycosylation, phosphorylation, proteolysis.

Description of instruction methods: lectures (for 5 or more students), individual consultations (for less than 5 students)
Description of course/module requirements: oral exam and seminar presentation of recent publication/s on the chosen specific subject covered by the course program
    H. Lodish, A. Berk,, C. A. Kaiser, M. Krieger, A. Bretscher, H. Ploegh, A. Amon, K. C. Martin, MOLECULAR CELL BIOLOGY 8th ed., W. H. Freeman & Co., New York 2016
    J.E. Krebs, E.S. Goldstein, S.T. Kilpatrick, Lewin's Genes XII, Oxford University Press, New York, 2017
    G.M. Cooper, R.E. Hausman: The Cell; a Molecular Approach, 7th ed., ASM Press, Washington, D.C., 2015
    R.J. White: Gene Transcription; Mechanisms and Control, Blackwell Science Ltd, Malden, USA, 2009
    Recent review papers from scientific journals: Annual Review of Biochemistry, Annual Review of Cell Biology, Trends in Biochemical Science, Trends in Genetics, Science, Nature
Consultations schedule: