1. komponenta

Lecture type	Total
Lectures	15

* Load is given in academic hour (1 academic hour = 45 minutes)

Control of gene expression: molecular mechanisms of transcriptional regulation in prokaryotes. Regulation of transcription - initiation in eukaryotes (cis-regulatory elements, general and specific transcription factors). Mechanisms of transcription factor activity regulation. Role of chromatin structure in transcription regulation (covalent modifications in histone tails and chromatin structure remodelling). Methods for analyzing protein-DNA and protein-protein interactions and chromatin structure analysis.
Post-transcriptional modification and processing of pre-mRNA (alternative splicing).
Transport of proteins through secretory pathways and into cell organelles. Co-translational translocation of secretory proteins across the ER membrane. Secretory pathway and vesicular transport. Signal sequences and molecular mechanisms of protein transport in mitochondria and nucleus.
Post-translational modifications of proteins. Protein folding, glycosylation, phosphorylation, proteolysis.

Description of instruction methods: lectures (for 5 or more students), individual consultations (for less than 5 students)
Description of course/module requirements: oral exam and seminar presentation of recent publication/s on the chosen specific subject covered by the course program


LEARNING OUTCOMES:
1. to show knowledge and understanding of biochemical reactions in the biosynthesis of nucleic acids and proteins
2. to interpret structure and catalytic mechanisms of enzymes and macromolecular assemblies participating in the transmission and flow of genetic information
3. to conclude about the importance of macromolecular interactions during transmission and flow of genetic information
4. to show knowledge and understanding of complex structure-function relationships between macromolecules participating in the transmission and flow of genetic information
5. to explain control mechanisms in the biosynthesis of nucleic acids and proteins with the emphasis on regulation of gene expression
6. to compare above mentioned biochemical processes and reactions in prokaryotes and eukaryotes

1. COMPULSORY LITERATURE:
   H. Lodish, A. Berk,, C. A. Kaiser, M. Krieger, A. Bretscher, H. Ploegh, A. Amon, K. C. Martin, MOLECULAR CELL BIOLOGY 8th ed., W. H. Freeman & Co., New York 2016
   J.E. Krebs, E.S. Goldstein, S.T. Kilpatrick, Lewin's Genes XII, Oxford University Press, New York, 2017
   G.M. Cooper, R.E. Hausman: The Cell; a Molecular Approach, 7th ed., ASM Press, Washington, D.C., 2015
   R.J. White: Gene Transcription; Mechanisms and Control, Blackwell Science Ltd, Malden, USA, 2009
2. ADDITIONAL LITERATURE:
   Recent review papers from scientific journals: Annual Review of Biochemistry, Annual Review of Cell Biology, Trends in Biochemical Science, Trends in Genetics, Science, Nature

Izborni kolegiji za smjer analitička kemija - Regular study - Analytical chemistry
Izborni kolegiji za smjer biokemija - Regular study - Biochemistry
Izborni kolegiji za smjer anorganska i strukturna kemija - Regular study - Inorganic and structural chemistry
Izborni kolegiji za smjer organska kemija - Regular study - Organic chemistry
Izborni kolegiji za smjer fizikalna kemija - Regular study - Physical chemistry

Izborni predmeti doktorski studij kemije - Regular study - Analytical chemistry
Izborni predmeti doktorski studij kemije - Regular study - Biochemistry
Izborni predmeti doktorski studij kemije - Regular study - Inorganic and structural chemistry
Izborni predmeti doktorski studij kemije - Regular study - Organic chemistry
Izborni predmeti doktorski studij kemije - Regular study - Physical chemistry