1. komponenta

Lecture type	Total
Lectures	60
Exercises	15

COURSE GOALS: Introduction to structure and reactivity of carbon compounds.

LEARNING OUTCOMES AT THE LEVEL OF THE PROGRAMME:
1. KNOWLEDGE AND UNDERSTANDING
1.2. demonstrate a thorough knowledge and understanding of the fundamental concepts in chemistry
1.4. demonstrate a thorough knowledge and understanding of the most important chemistry laws and theories laws and theories
2. APPLYING KNOWLEDGE AND UNDERSTANDING
2.2. describe important aspects of chemical change
5. LEARNING SKILLS
5.1. search for and use professional literature as well as any other sources of relevant information

LEARNING OUTCOMES SPECIFIC FOR THE COURSE:
Students will be able:
1. to represent organic molecules in space using structural formulae and give them names using IUPAC nomenclature
2. to write and to explain the mechanisms of elimination reactions, electrophilic additions on unsaturated and conjugated substrates, pericyclic reactions and electrophilic and nucleophilic aromatic substitution
3. explain the influence of structure on reactivity of organic molecules
4. to define aromaticity and antiaromaticity and explaine on examples
5. to plan a multistep synthesis of simple organic compounds on the basis of acquired knowledge in organic chemistry
6. to connect structure of biologically important molecules with their biological role.

COURSE DESCRIPTION:
1. Elimination reactions
1.1. Mechanisms and stereochemistry of elimination reactions
1.2. Elimination versus substitution
2. Electrophilic additions to unsaturated carbon
2.1. Mechanisms and stereochemistry of addition reactions
2.2. Addition to conjugated dienes and conjugated carbonyl compounds
2.3. Homogenic and heterogenic catalysis
3. Pericyclic reactions
3.1. (4 + 2) cycloaddition and dipolar cycloaddition
3.2. Orbital symetry control of pericyclic reactions (HOMO-LUMO and correlation diagram methods)
3.3. Electrocyclic reactions and sigmatropic rearrangements
4. Electrophilic aromatic substitutions
4.1. Aromatic and antiaromatic compounds
4.2. Mechanism of electrophilic aromatic substitution
4.3. Substituent effects on orientation in electrophilic aromatic substitution
4.4. Reactions of heteroaromatic compounds
5. Nucleophilic aromatic substitution
6. Molecular rearrangements
7. Free radical reactions
8. Organic synthesis
8.1. Design of a synthesis (starting materials, construction reactions, functional group
interconvesions and protecting groups)
8.2. Retro-synthetic approach
9. Natural organic compounds
9.1. Carbohydrates
9.2. Amino acids and proteins
9.3. Lipids
9.4. Alkaloids
9.5. Pheromones

REQUIREMENTS FOR STUDENTS:
Attendance to lectures and exercises.

GRADING AND ASSESSING THE WORK OF STUDENTS:
Written and oral final exam.

1. Organska kemija, L. G. Wade ml., Školska knjiga, Zagreb, 2017.
2. Organic Chemistry (8th Ed.), L. G. Wade Jr., Pearson Education Inc., London,., 2013.
3. Organic Chemistry (8th Ed.), F. A. Carey, R. M Giuliano, McGraw-Hill, New York, 2010.

Enrollment :
Attended : Organic chemistry 1
Attended : Physical Chemistry

Examination :
Passed : Organic chemistry 1
Passed : Physical Chemistry

Mandatory course - Regular study - Physics and Chemistry Education