MAJA KUZMAN – OBRANA DOKTORSKOG RADA

 

Naslov:Identification and characterization of transposable elements in sponges (Porifera)

Identifikacija i karakterizacija pokretnih genetičkih elemenata u spužvama (Porifera)

Obrana će se održati u utorak, 29. rujna 2020. godine u 14,00 sati putem on-line videokonferencije- zainteresirani za dobivanje poveznice za pristup obrani molimo da se jave na mail pdsbiol@biol.pmf.hr

 

Povjerenstvo za obranu:

dr. sc. Helena Ćetković, znanstvena savjetnica, Institut Ruđer Bošković, Zagreb

prof. dr. sc. Petr Svoboda, Institute of Molecular Genetics, Češka

doc. dr. sc. Rosa Karlić, PMF, Zagreb

zamjena: prof. dr. sc. Višnja Besendorfer, PMF, Zagreb

 

Mentor:

prof. dr. sc. Kristian Vlahoviček, PMF, Zagreb

 SAŽETAK

Transposable elements constitute a large portion of most eukaryotic genomes and play an important role in transcriptional regulation, shaping gene regulatory networks and genome evolution. Due to a lack of quality genome assemblies of non-model organisms, not much is known about the diversity, distribution and the role of transposable elements across Metazoa. In this thesis I present high quality genome assemblies for the sponge species Eunapius subterraneus and Suberites domuncula. I use computational genomics techniques to identify, characterize and compare transposable elements in the publicly available sponge genomes and in-house assembled genomes by analysing the abundance and conservation of the transposable elements in different sponge species. I assess the impact of transposable elements on the evolution of the host genomes by analysing their contribution to genome organization and correlation with gene expression. Finally, I present a catalog of the homologs of piRNA pathway in sponges and analyse their transcriptional activity.

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